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There is no cure, and patients deteriorate gradually. ‘Surgical removal is not an option because this would cause more trauma, and as a result, more bone growth.’ ‘With FOP, any fall or bump can stimulate the faulty ACVR1 receptors present in all cells, triggering the production of bone in areas of soft tissue, such as muscles and ligaments,’ says Professor Richard Keen, a consultant in metabolic bone disease at the Royal National Orthopaedic Hospital in London, and a specialist in FOP. However, if someone is born with the mutation, there is a 50 per cent chance they will pass it on. This mutation usually happens randomly rather than being passed on. In fact, rare diseases affect one in 17 people in the UK, and 75 per cent of these diseases affect children.įOP is caused by the mutation of a gene called ACVR1, which helps to control the growth of new bone. It is individually rare, but there are more than 7,000 known rare conditions, and approximately 80 per cent of these are linked to genes, says Samantha Barber, CEO of the charity Gene People.
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‘We planned to grow old here - but it’s much more important to keep Lexi safe,’ says Alex.Įventually, they plan to build a bungalow customised to Lexi’s needs, including wide doorways (to reduce the chance of bumps) and no steps - and they intend to keep her at home rather than send her to nursery.įOP, which is diagnosed via a genetic test, affects around 60 people in the UK, or one in a million. They’re also selling their forever home - a ‘higgledy-piggledy’ four-bedroom cottage in Hemel Hempstead - to move into a bungalow or a flat. In preparation for Lexi taking her first steps, Alex and her husband David, 39, a sales manager, have covered every sharp corner or ledge in their home with padding to cushion future bumps. ‘It’s a fine balance between allowing Lexi to develop normally and keeping her safe. He’s a boisterous three-year-old - but he doesn’t have FOP and accidents happen. ‘She’s a happy, sassy little girl who always wants to copy her older brother Ronnie. ‘We’ll always be on edge, with eyes in the back of our heads.
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‘We are very anxious about Lexi becoming mobile,’ says Alex, 30, an events manager. Most FOP patients die prematurely, in their 40s and 50s. Others find the extra bone growth around their ribcage restricts their breathing, making them prone to infections.
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Thought to be one of the rarest and most disabling conditions known to medicine, fibrodysplasia ossificans progressiva (FOP) causes a lattice of bone to grow throughout the body, gradually paralysing the person, joint by jointĪround one in three develops partial or full hearing loss because of the fusion of bones in their ears.